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Mailing Address
M. Nazmul Huda, Ph. D
Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh.
Email: adina52@hotmail.com
Academic qualification
Ph. D: Department of Microbiology, Fact of Pharmaceutical Sciences, Okayama University, Japan, March, 2002.
Thesis Title: Molecular genetic analysis and biochemical characterization of multidrug effux pumps in Vibrio cholerae non-01.
M. Sc: Department of Biochemistry, University of Dhaka, (1988)
B. Sc: Department of Biochemistry, University of Dhaka, (1987)
Research Interests:
Antibiotic resistance in the community is a growing threat particularly in developing countries. Bacteria can be resistant in their natural state or they can acquire resistance genes by mutation, expression of a latent chromosomal gene or by exchange of genetic material from other bacteria. They are a number of mechanisms by which bacteria perform their resistant activity. Among them, multidrug efflux pump is one of the common and major mechanisms. I have cloned and characterized three multidrug efflux genes from Vibrio cholerae non-01. Two of them belong to the MATE family and the rest one belong to ABC-type multidrug transporter. I like to find some inhibitor(s) from the natural sources that would be a potent inhibitor of the efflux pumps.
Selected Publications:
1. Chen. J., Morita. Y., Huda, M. N., Kuroda, T., Mizushima, T., and Tsuchiya. Y 2002 Vmr, member of a novel class of Na+-coupled multidrug efflux pump from Vibrio parahaemdytiens, J. Bacteriol. 184 (2): 572-576
2. Huda M. N., Morita, Y. Kuroda, Y., Mizushima, T., and Tsuchiya, T. 2001. Na+-driven multidrug efflux pump VeaM from Vibrio cholerae non-01, a non-halophilic bacterium. FEMS Microbiol. Letts, 203: 235-239.
3. Kaneko, J., Mascarenas, A. L., Huda, M. N., Tomita, T., and kamio, Y. 1998. An N-terminal region of LukF of Staphylococcal Leukocidin/gama-hemolysis crucial for the biological activity of the toxin.Biosci, Biotechnol, Biochem. 62(7): 1465-1467.
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