| Teaching
Staff Department of Genetic Engineering & Biotechnology University of Dhaka Ramna, Dhaka- 1000, Bangladesh |
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| Back to Faculty Index | |||||
| Dr. Md. Anwarul Azim Akhand | |||||
| Full Time Faculty, GEB | |||||
| Chairman,
Department of Genetic Engineering & Biotechnology, University
of Dhaka |
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Date of Birth: 1/1/1966 Nationality: Bangladeshi |
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Personal/Contact
Address 3.July 2002 until
todate: Asst.Professor, Department of Genetic Engineering and Biotechnology,
University of Dhaka Academic
Award 2. Obtained the
scholarship of Ministry of Education, Science, Sports and Culture of
Japan (Monbusho) for the PhD. course. Professional
Society Editorial Board
Membership Other Activities Cell Biology: Tissue culture techniques for primary and established cell lines, and cell lines expressing stably transfecting genes. Immunology: Working knowledge of monoclonal/polyclonal antibody development (immunization of mice/rabbit, production and maintenance of hybridomas, screening of hybridoma cultures), immunoblotting and immune precipitation of cell lysates, fluorescence antibody technique and FACS (fluoresceine-activated cell sorter) analysis. Biochemistry:
SDS-PAGE, in vivo and in vitro kinase assay, phosphoamio acid analysis
of peptides, cyanogn bromide cleavage mapping of peptides, kinetic measurement
of Km and Vmax of enzymes, agarose gl electrophoresis, TUNEL assay for
determining apoptosis, [3H]thymidine uptake assay 1. Ali M. S. Akhand
A. A. (1992) Cellulose from Trichoderma isolate. J. Basic Microbiol.
32, 259-268. 6. Pu M., Akhand
A. A. Kato M., Hamaguchi M., Koike T., Iwata H., Sabe H., Suzuki H.
and Nakashima I. (1996) Evidence of a novel redox linked activation
mechanism for the Src Kinase which is independent of tyrosine 527-mediated
regulation. Oncogene, 13, 2615-2622. 7. Akhand A. A., Pu M., Du J., Kato M., Suzuki H., Hamaguchi M. and Nakashima I . (1997) Magnitude of protein tyrosine phosphorylation-linked signal determines growth versus death of thymic T lymphocytes Eur. J . Immunol. 27, 1254-1259. 8. Nakashima I., Pu M., Akhand A. A., Kato M. and Suzuki H. (1997) Chemical events in signal transduction (Letter). Immunol. Today. 18, 362. 9. Nakashima I., Pu M., Akhand A. A., and Kato M. (1997) Sulfhydryl-based regulation of Src family protein tyrosine kinase for cell growth and death. In Proceedings of the Jakarta International Cancer Conference, editd by Berkel H, Faculty Medicine University Press, Jakarta. pp231-240. 10. Ohkusu K., Du J., Isobe K., Yi H., Akhand A. A., Kato M., Suzuki H., Hidaka H., and Nakashima I. (1997), Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL- lpr/lpr mice, Eur. J. Immunol. 25, 3180-3186. 11. Liu ., Kato M., Akhand A. A., Hayakawa A., Takemura M., Yoshida S. Suzuki H. and Nakashima I. (1998). The herbal medicine sho-saiko-to inhibits the growth of malignant cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulating of cyclin dependent kinase. Int. J. Oncol. 12, 1321-1326. 12. Akhand A. A.,
Kato M., Suzuki H., Miyata T. and Nakashima I. (1998). Level of Hgcl2-mediated
phosphorylation of intracellular proteins determines death of thymic
T lymphocytes with or without DNA fragmentation. J. Cell. Biochem. 71,
243-253. Back to top 14. Parashar A.,
Akhand A. A., Rawar R., Furuno T., Nakanishi M., Kato M., Suzuki H.
and Nakashima I. (1999). Mercuric Chloride Induces Increases in both
Cytoplasmic and Nuclear Free Calcium Ions through a Protein Phosphorylation-Linked
Mechanism. Free Rad. Biol. & Med. 26,227-231. 15. Akhand A. A., Kato M., Suzuki H., Liu Wei L., Du J., Hamaguchi M., Miyata T.,Kurokawa k. and Nakashima I. (1999). Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src. J. Cell. Biochem. 72, 1-7. 16. Kato M., Liu W., Akhand A. A., Dai Y., Ohbayashi M., Suzuki H., Isobe K., Takahashi M. and Nakashima I. (1999). Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines. Oncogene. 18, 837-842. 17. Nakashima I.,
Akhand A. A., Pu M., Kato M., Hamaguchi M., Senga T., Suzuki H., Parashar
A., Du J. and Liu W, Umeda Y and Miyata T. (1999). Redox-oriented chemical
events in signal transduction in cells. In Redox Regulation of Cell
Signaling and its Clinical Application (Eds. L. Packer and J. Yodoi).
Marcel Dekker, Inc., New York. Pp 177-204. 18. Liu W., Akhand
A. A., Kato M., yokoyama I., Uchida K., Miyata T., Kurokawa K. and Nakashima
I. (1999). 4-Hydroxynonenal triggers epidermal growth factor receptor-linked
signal pathway for growth inhibition. J. Cell Sci. 112. 2409-2417. 19. Akhand A. A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M. and Nakashima I. (1999). Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr527-independent and Tyr416-linked mechanism. J. Biol. Chem. 274, 25821- 25826. 20. Kato M., Iwashita T., Takeda K., Akhand A. A., Liu W., Yoshihara M. Asai N., Suzuki H. and Nakashima I. (2000). Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases. Mol. Biol. Cell. 11, 93-101. 21. Liu W., Kato
M., Akhand A. A., Hotta Y., Ishikawa N., Hayakawa A., Suzuki H., Miyata
T., Kurokawa K and Nakashima I. (2000). 4-hydroxynonenal induces a cellular
redox status-related activation of the caspase cascade for apoptotic
cell death. J. Cell Sci. 113, 635-641. 22. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., Miyata T., Kurokawa K., and Nakashima I (2000). Methylglyoxal Induces Apoptosis in Jurkat Leukemia T-cells by Activating c-Jun N-terminal Kinase. J. Cell. Biochem. 77, 333-344. 23. Nakashima I.,
Akhand A. A., Kato M., Du J., Liu W., Hossain K., Suzuki H., Wu J.,
Takeda K., and Yoshihara M. (19990. oxidative stress and signal transduction
in the immune system. Recent Res. Devel. Immunol. 1, 283-296. 24. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., and Nakashima I. (2000). Mercuric chloride stimulates distinct signal transduction pathways for DNA synthesis in a T cell line. CTLL-2. J. Cell. Biochem. 78, 500-508. 25. Kato M., Iwashita T., Akhand A. A., Liu W., Takeda K., Takeuchi K, Yoshihara M., Hossain K., Wu J., Oh C., Fujitani S., Shimuzu Y., Sobajima Y., Takahashi M. and Nakashima I. (2000). Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation. Antioxidants and Redox Signal. 2, 841-849. 26. Hossain K.,
Akhand A. A., Kato M., Du J., Takeda K., Wu J., Takeuchi K., Liu W.,
Suzuki H. and Nakashima I. (2000). Arsenite Induces Apoptosis of Murine
T Lymphocytes Through Membrane Rafts-Linked Signaling for Activation
of c-Jun Amino Terminal Kinase (JNK). J. Immunol. 165, 4290-4297. 27. Nakashima I., Kato M., Akhand A. A., Du J., Liu W., Dai Y., Suzuki H., Senga T., Hamaguchi M., Iwashita T., Takahashi M., Miyata T., Hossain K., Wu J., Takeuchi K., Yoshihara M. and Kawamoto Y. (2000). Chemical reaction-mediated alternative signaling pathway in cells of the immune system. Curr. Trends Immunol 3, 45-58. 28. Kato M., Liu
W., Akhand A. A., Hossain K., Takeda K., Takahashi M. and Nakashima
I (2000). Ultraviolet radiation induces both full activation of Ret
kinase and malignant melanocyte tumor promotion in RFP-RET-transgenic
mice. J. Invest. Dermatol. 115, 1157-1158. 29. Takeuchi K., Kato M., Suzuki H., Akhand A. A., Wu J., Hossain K., Miyata T., Matsumoto Y., and Nakashima I. (2000). Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death J. Cell. Biochem. 81, 679-688. 30. Akhand A. A.,
Hossain K., Mitsui H., Kato M., Miyata T., Inagi R., Du J., Takeda K.,
Kawamoto Y., Suzuki H., Kurokawa K., Nakashima I. (2000). Glyoxal and
methylglyoxal trigger distinct signals for MAP family kinases and caspase
activation in human endothelial cells. Free Radic Biol Med. 31, 20-30. 31. Miyata T., Akhand A. A., Kurokawa K., Nakashima I. (2000) Reactive carbonyl compounds as uremic toxins. Contrib Nephrol. 133, 71-80. 32. Wu J., Suzuki H., Zhou Y., Liu W., Yoshihara M., Akhand A. A., Hayakawa A., Takeuchi K., Hossain K., Kurosawa M., and Nakashima I. (2000). Cepharanthene activates caspase and induces apoptosis in Jurkat and K562 human leukemia cell lines. J. Cell. Biochem. 82, 200-214. 33. Du J., Suzuki H., Nagase F., Akhand A. A., Ma X-Y., Yokoyama T., Miyata T., and Nakashima I. 2000. Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic Biol Med. 31, 469-478. 34. Dai Y., Kato
M., Takeda K., Kawamoto Y., Akhand A. A., Hossain K., Suzuki H., and
Nakashima I. (2001). T-cell immunity-based inhibitory effects of orally
administered herbal medicine Juzen-taiho-to on the growth of primarily
developed melanocytic tumors in Ret-transgenic mice. J. Invest. Dermatol.
117, 694-701. 36. Wu J., Suzuki H., Akhand AA., Zhou Y., Hossain K., and Nakashima I. (2002). Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells. Cell Signal. 14, 509-515. 37. Kato M., Takeda K., Kawamoto Y., Iwashita T., Akhand A. A., Senga T., Yamamoto M., Sobue G., Hamaguchi M., Takahashi M. and Nakashima I. (2002). Repair by Src kinase of function-impaired RET with multiple endorcrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res. 62, 2414-2422. 38. Nakashima I.,
Suzuki H., Kato M. and Akhand A. A. (2002) Redox control of T-cell death.
Antioxide. Redox Signal. 4, 353-356. 42. Ruhul Amin A. R., Machida K., Oshima K., Oo M. L., Thant A. A., Senga T., Matsuda S., Akhand A. A., Maeda A., Kurosaki T. and Hamaguchi M. (2002). A role for SHPS-1/SIRPa1 in IL-1ß- and TNFa-dependent signaling. Oncogene. 21, 8871-8878.
Presentation
in Scientific Conferences 3. Attended the
First International Conference on Redox and Signal Information, 1993
held in Kyoto. 9. Attended the
25th Annual Conference, 1995 of the Japanese Society for Immunology
held in Fukuoka and participated in the poster session. 10. Attended the
26th Annual Conference, 1996 of the Japanese Society for Immunology
held in Yokohama and participated in the poster session. 14. Attended the
28th Annual Conference, 1998 of the Japanese Society for Immunology
held in Kobe and participated in the workshop for presenting posters.
19. Hossain K.,
Akhand A. A., Kato M., Du J., Takeda K., Wu J., Tsuboi H., Suzuki H.,
and Nakashima I. Arsenic induces membrane-raft linked apoptotic signals
in murine thymic Tlymphocytes. Proc. Jpn. Soc. Immunol, Vol. 30, pp.
272. (abstract). |
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