Syllabus for Masters in Genetic Engineering and Biotechnology
GEB 501 : Computational Genomics and Systems Biology (4 credits)
1. Computational Genomics: Genetic and physical map of a genome, Genome sequencing and assembly of contigs.
2. Comparative analysis of genomes from multicellular eukaryotes: the Gene Ontology in comparative genomics, Genomics and developmental biology of Drosophil a .
3. Sequence analysis and evolution of RNA genes: Computational identification of RNA genes in genomic DNA, RNA interference (RNAi), Micro RNAs and gene regulation.
4. Applications of genome analysis: in identification of drug targets.
5. Introduction to Computational Systems Biology: Systems Biology- a new approach to decoding life.
6. Molecular systems biology: constructing and modelling of genetic networks, control theory and genetic networks.
7. Cellular systems biology: local activation and global inhibition models, gradient sensing systems.
8. Developmental systems biology: general pattern formation models, Comparative systems biology: cross-species comparison of networks.
9. Biological Networks: Network biology, understanding the cell's functional organization, reconstructing transcriptional regulatory modules and networks,
10. Protein-Protein Interaction (PPI) Networks: biological experiments, computational techniques and analyses databases.
11. Metabolic Networks: structural properties of metabolic networks, modeling metabolic networks. Designer Networks: Engineered Gene Circuits.
12. Microarray analysis an introduction: Computational biology to understand the complex biological systems.
13. Microarray technologies: data processing: image analysis, normalization. Design microarray experiments and data analysis.
14. Applications of Microarray in identification of complex genetic diseases: drug discovery, mutation and polymorphism detection (SNPs) and differing expression of genes over time, between tissues and disease states.
References:
1. From molecular to modular cell biology, L H Hartwell, J J Hopfield, S Leibler & A W Murray, Nature 402, C47 - C52 (1999)
2. A New Approach To Decoding Life: Systems Biology Trey Ideker, Timothy Galitski, Leroy Hood Annual Review of Genomics and Human Genetics Sep 2001, Vol. 2: 343-372.
3. Computational systems biology, H. Kitano, Nature 420, 206 - 210 (2002).
4. Systems Biology: A Brief Overview, H. Kitano, Science, 295, 1662-1664, 2002.
5. Genomics, gene expression and DNA arrays, Lockhart, D.J. and Winzeler, E.A. 2000, Nature 405: 827-836.
6. Detecting Protein Function and Protein-Protein Interactions from Genome Sequences. Edward M. Marcotte, Matteo Pellegrini, Ho-Leung Ng, Danny W. Rice, Todd O. Yeates, David Eisenberg.
7. Predictome: a database of putative functional links between proteins, J. C. Mellor, I. Yanai, K. H. Clodfelter, J. Mintseris, and C. DeLisi, Nucleic Acids Res., January 1, 2002; 30(1): 306 - 309.
8. Whole-genome annotation by using evidence integration in functional-linkage networks. Karaoz U, Murali TM, Letovsky S, Zheng Y, Ding C, Cantor CR, Kasif S. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2888-93. Epub 2004 Feb 23. PMID: 14981259
9. Whole-proteome prediction of protein function via graph-theoretic analysis of interaction maps. Nabieva E, Jim K, Agarwal A, Chazelle B, Singh M. Bioinformatics. 2005 Jun 1;21 Suppl 1:i302-i310.
10. A novel genetic system to detect protein-protein interactions Fields, S. and Song, O. 1989. . Nature 340: 245-246.
11. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae Uetz, P. et al., Nature 403: 623-627, 2000.
12. The large-scale organization of metabolic networks Jeong et al., Nature. 2000 Oct 5;407(6804):651-4
13. Hierarchical Organization of Modularity in Metabolic Networks, Ravasz et al., Science. 2002 Aug 30;297(5586):1551-5
14. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Ideker T, Thorsson V, Ranish JA, Christmas R, Buhler J, Eng JK, Bumgarner R, Goodlett DR, Aebersold R, Hood L. Science. 2001 May 4;292(5518):929-34.
15. Computational studies of gene regulatory networks: in numero molecular biology. Hasty, J., McMillen, D., Isaacs, F. & Collins, J. J. Nature Rev. Genet. 2, 268-279 (2001).
16. GENETIC "CODE": Representations and Dynamical Models of Genetic Components and Networks Alex Gilman and Adam P. Arkin. Annual Review of Genomics and Human Genetics Sep 2002, Vol. 3, pp. 341-369.
17. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models, Hucka M et al. Bioinformatics. 2003 Mar 1;19(4):524-31. PMID: 12611808
18. Construction of a genetic toggle switch in Escherichia coli. Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339-342 (2000).
19. A synthetic oscillatory network of transcriptional regulators. Elowitz, M. B. & Leibler, S. Nature 403, 335-338 (2000).
20. Yang YH, Buckley MJ, Dudoit S, Speed TP (2000) Comparison of methods for image analysis on cDNA microarray data. Technical Report 584, Department of Statistics, UC-Berkeley.
21. Yang YH, Dudoit S, Luu P, Speed TP (2000) Normalization for cDNA microarray data. Technical Report 589, Department of Statistics, UC-Berkeley
22. Kerr and Churchill(2001), Experimental design for gene expression microarrays, Biostatistics, 2:183-201.
23. 4. Dudoit S, Yang YH, Callow MJ, Speed TP (2000) Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments. Technical Report, Department of Statistics, UC-Berkeley.
GEB 502 : Oncology and Virology (4 credits)
A. Oncology:1. Definitions and terminologies, benign and malignant tumor : Biology and tumor cell growth, clonality and kinetics of tumor cell growth, host facotrs, affecting tumor cell growth, in vitro (i) tumor cell growth, karyotypic changes in tumors.
2. Metastasis : Pathways and mechanism. Transformation of a normal cell to its malignant counterpart, and the consequences of malignant transformation on the cellular and organism level. Transformation process from the initial cellular damage and stepwis tumor evolution to the clinical picture, diagnostics and cancer therapy.
3. Causes of Cancer : Carcinogenic agents and their cellular interactions :
(i) Chemical carcinogenesis mechanism of chemical carcinogenesis and carcinogenic chemicals.
(ii) Radiation carcinogenesis UV rays, ionizing radiation, mechanism of radiation carcinogenesis, viral carcinogenesis.
(iii) Oncogenesis DNA and RNA ioncogenic viruses, mechanism of viral oncogenesis.
4. Oncogenes and cancer : Cancer related genes, including oncogenes, tumor suppressor genes and DNA-repair genes their normal cellular function, mutagenesis and consequences of theri mutant state in cancer, actication of proto-ncogene, cancer suppressor genes (antioncogenes). Hereditary cancer.
5. Host tumor interactions : Effect of tumorion host, host defense against tumors. Tumor biology : The biological behaviour of tumors. Cell cycle control and apoptosis, Growth factors. Tumor progression and metastasis. The stepwise transformation process. The interaction between malignant and normal cells. Tumor virology. Research methodology.
6. Malignant disease : Dianosis. Molecular tumor pathology. The major treatment principles of cancer (surgery, radiotherapy, hormonal treatment, and biological therapy. Novel and developing treatment strategies. Cancer epidemiology. Prevention, Clinical trials.
7. Human cancer : Biochemical tests and laboratory diagnosis of cancer : Treatment of cancer. Breast Cancer : A case study.
B. Virology :
1. Major groups of viruses : Bacterial, plant and animal viruses with their nomenclature and classification.
2. Cultivation, detection and assay of virus : Serological and molecular detection plaque assay (PFU). Infectious center assay, one-hit kinetic and two-hit kinetics of virus cultivation.
3. Host virus interaction : Attachment, entry and uncoating, replication, assembly and maturation exit of virus from host cells.
4. Animal virus : Classification based on gene expression studies on virion structure, infectivity, mode of gene expresion and virus assembly.
5. Effect of animal viruses on host cells : Cytolytic effect, morphological and biochemical observations, inhibitions of proteins, RNA and DNA synthesis, pattern of viral infection-acute, chronic, persistent and latent viral infection.
6. Genetic variability in viruses : Viral modulation of the cell cycle (1) Viral interferences with antigen presentation mechanisms ; (2) vital evasion of cellular immune responses ; (3) viral inhibitors of chemokines ; and (4) viral inhibitors of apoptosis.
7.Virus Transformation of Cells : Mechanisms of Cell Transformation, RNA Transforming Viruses, DNA Transforming Viruses, Tumour Suppressor Proteins
8. Prevention and control of viral infection : General prevention strategies. Immunization I with vaccines and antiviral drugs, mechanism of action and limitations of use of these drugs. RNA interference-antiviral effects and viral modulation of RNAi RNAi for modulating viral (HIV, Hepatitis C) replication ; RNA interference for treating cancers caused by viral infection.
9. Viral Immunopathogenesis : Immune response to viral infection, Pathogenesis of AIDS, SARs and Dengue. Advances in HIV molecular biology.
10. Interferon : Chemical nature and classification, Induction of interferon synthesis and development of antiviral state by interferon, molecular basis of interferon actions, viral interference not mediated by interferon.
References :
1. Molecular Oncology
Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington ; The Basic Science of Oncology. McGraw-Hill, 4th ed. 2005
2. Principles of Molecular Virology, 4th edition
Alan Cann
Academic Press
3. Molecular Virology
DR Harper, DR Harper and PR Kinchingtion
4. Principles of Molecular Oncology
M.H> Bronchud, M.A. Foote, G. Giaccone, O. Olopade, P Workman (eds). Second edition, Humana Press, 204
http://www. Tulane.edu~dmsander/WWW/335/Trans2.html
5. Genomics, gene expression and DNA arrays, Liockhart, D.J. and Winzeler, E.A. 2000, Nature 405 : 827-836
6. Detecting Proteins Function and Protein-Protein interactions from Genome Sequences. Edward M. Marcotte, Matteo Pellegini, Ho-Leung Ng, Danny W. Rice, Todd O. Yeates, David Eisenberg.
7. Predictorme : a database of putative functional links between proteins, J.C. Mellor, I. Yanai, K.H. Clodgelter, J, MIntseris, and C. DeLIsi, Nucleic Acids Res., January 1, 2002 ; 30(1) : 306-309
8.Whole-genome annotation by using evidence integration in functional-linkage networks. Karaoz U, Murali TM letovsky S, Zheng Y, Ding C, Cantor CR, Kasif S. Proc Natl Acad Sci USA. 2004 Mar 2, 101 (9) 2888-93, Epub 2994 Feb. 23, PMID : 14981259
9. Whole-proteome predition of protein function via graph-theoretic analysis of ineraction maps. Nabieva E. Jim K, Agarwal A, Chazelle B, Singh M. Bioinformatics, 2005 JUn 1; 20 Suppl 1 : i302-i310
10. A novel genetic system to detect protein-protein interactions Fields, S. and Song, O. 1989., Nature 340; 245-246
11. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae Uetz, P. et al., Nature 403 : 623-627, 2000.
12. The large-scale organiztion of metabolic networks Jeong et al., Nature 2000 Oct 5: 407 (6804) : 651-4.13. Hierarhical Organization of Modularity in Metabolic Networks, Ravasz et al., Science. 2002 Aug 30.297 (5586) : 1551-5
14. Integrated genomic and proteomic analyses of a systematically perturbed Metabolic network, Ideker T, Thorsson V, Rahish JA, Christmas R, Buhler J, Eng. Jk, Bumgarner R, Good lett DR. Aeber-sold R, Hood L. Science. 2001 Mya 4; 292 (5518) : 929-34
15. Computational studies of gene regulatory networks in numero molecular biology, Hasty, J., McMillen, D., Issacs F. & Collins, J.J. Nature Rev. Genet. 2 268-79 (2001)
16. GENETIC "CODE" : Represenations and Dynamical Models of Genetic Components and Networks Alex Gilman and Adam P. Arkin. Annual Review of Genomics and Human Genetics Sep, 2002, Vol. 3 pp. 341-369
17. The systems biology markup language (SBML) a medium for representation and exchange of biochemical network models, Hucka M et al. Bioinformatics, 2003 Mar 1 ; 19 (4) ; 524-31. PMID 12611808
18. Construction of a genetic toggle switch in Escherichia coli. Gardner, T.S.; Cantor, C.R. & Collins, J.J. Nature 403 339-342 (2000)
19. A synthetic oscillatory network of transcriptional regulatros. Elowitz, M.B. & Leibler, S. Nature 403, 335-338 (2000)
20. Image analysis on cDNA microarray data Technical Report 584, Department of Statistics, UC-Berkeley
22. 2. Yang YH, Duoit S, Luu P, Speed TP (2000) Comparison of methods for image analysis on cDNA microarray data Technical Report 584 UC-Berkeley
23.Kerr and Churchill (2001), Experimetal design for gene expression microarrays, Biostatistics, 2 : 183-201.
24. 4. Dudoit S, Yang YH, Callow MJ Speed TP (2000) Statistical methods for identifying differentially expresssed genes in replicated cDNA microarray experiments, Technical Report, Department of Statistics, UC-Berkeley.
GEB 503 : Immunology and Immunodiagnosis (4 credits)
1. Immunoglobulin genes and antibody diversity : Immunoglobulin genes ; Isotypic, allotypic and idiotypic variations ; Somatic mutation and somatic recombination ; theories of antibody formation ; Evidences for Dreyer and Benett’s hypothesis for recombination of V and C genes ; Molecular mechanism of recombination between immunoglobulin gene segments; generation of antibody diversity.
2. Membrane receptors for antigen : B-cell receptor (BCR) ; T-cell antigen receptor, genes of the TCR, generation of diverse TCRs by recombination of V.D. and J segments, transcriptional control of TCR genes ; NK receptors, mechanism of cytotoxicity, induction of apoptosis by cytotoxic T-cells and NK cells, apoptosis mediated by caspases, Fas or TNF receptor-mediated signals for cytotoxicity. ; Major histocompatibility complex (MHC) genomic organization and expression, transcriptional regulation of MHC expression, HLA-disease association.
3. T cell activation and signal transduction, by the TCR complex : General features of T lymphocyte activation roles of costimulators in T cell activation ; intracellular signaling events during T cell activation ; involvement of tyrosine kinase/phosphateases ; Ras-MAP kinase signaling pathways in T lymphocytes ; Ca and PKC-mediated signaling pathway, in T lymphocytes ; activation of transcription factors that regulate T-cell gene expression.
4. Cytokine and cytokine receptors : Cytokines and cytokine receptor families, defects in cytokine receptors and diseases, basic model for cytokine activation, intracellular signaling pathways induced by IFN and TNF, cytokine production by the T-cell subsets, proinflammmatory cytokines, chemokine family, Cytokine network, cytokine diseases and therapies.
5. B-cell development and cell cooperation : Primary B-cell development, activation of B-cells by T-dependent and independent antigens ; cell surface molecules involved in T and B-cell interaction ; stages in B-cell activation and development, B-cell development in germinal center ; B-cell differentiation, somatic mutation and receptor editing, recombination heavy chain genes for class switching, class switching by gene recombination and differential splicing of mRNA ; production of membrane and secreted IgM.
6. Regulation of the immune responses : Regulation by antigen ; regulation by antibody ; regulation by lymphocytes ; regulation by NK and NK T-cells ; regulation by localization of cells ; idiotypic modulation of responses ; neuroendocrine modulation of immune responses ; Genetic control of immune responses.
7. Haematology : Full blood count, differential count, erythrocyte sedimentation rate blood transfusion, transfusion reaction.
8. Diagnostic procedures:
(i) Immunoassays : Enzyme immunoassays in diagnosis of bacterial and viral infection, microparticle enzyme immunoassays for detection of HCV and other viral infections, radioimmunoassay, immunoturbidometry, immunofluoresecence, fluorescence activated cell sorter (FACS).
(ii) Assay for antigen : HbcAg, HbsAg, Western blotting for identifying antigen and antibody, ammonium sulfate precipitation of Ag-Ab complex, assay for tumor markers.
(iii) Assays for antibodies : IgG, IgM, IgE, anti-HBV DNA, assay of antibody in thyroid diseases (T3, T4 assays), anti-double stranded and anti-single stranded DNA antibodies, autoimmune hemolytic anemia, autoimmune diabetes, pernicious anemia, diagnostic and prognostic value of auto-antibodies, Ferritin-conjugated antibodies for electron microscopy, complement deficiencies.
(iv) Immunoasssyas of hormones : Estrogen, progesterone, cortisone, prolactine, latex agglutination test.
(v) Chromosomal aberration
9. Other immunotechniques : Haemagglutination titer and assay for Ab-secreting cells, separation and identification of protein or antigen, hybridoma technology and monoclonal antibodies, side effects of antibody therapy, gene-targeted knockout mice, knock-in technology, SCID mice and SCID-human mice.
10. Hazards and quality control in diagnostic laboratory : Hazards from dangerous chemicals, infected specimens and faulty apparatus ; Precision, accuracy reference value, interpretation of results.
References:
1. Immunology (6th edition)
Ivan Roitt, Janathan Brostoff and David Male Mosby, Harcourt Publishers.
2. Roitt’s Essential Immunology (10th edition)
Ivan Roitt, and Peter J. Delve
Blackwell Science
3. Cellular and Molecular Immunology (5th edition)
Abul K. Abbas and Andrew H. Lichtman
Saunders, Elsevier Science.
4. Immunology and Immunopathology
Ashim K. Chakravarty
Oxford University Press
5. Clinical Immunology
Provash Sen Gupta
Oxford University Press
6. Basic and Clinical Immunology
Mark Peakman and Diego Vergani
Elsevier Science
7. Text book of Biochemistry with Clinical Correlations
Thomas M. Devlin
John Wiley and Sons
GEB 504 : Food and pharmaceutical Biotechnology (4 credits)
1. Fermentation Technology:
a. Fermentor/bioreactor : Types, configuration, mixing and aeration; power requirements, impeller designs, baffle and aeration, Membrane bioreactor.
b. Inoculums preparation and inoculums development,
c. Fermentation modeling : Rate equations of cell growth substrate utilization, product formation, transfer across phase boundaries.
d. Mode of fermentation : Fed, batch and continuous culture ; process and its control. pH, dissolve oxygen and relates sensors.
2. Food and Enzymes:
a. Production of Cultures for Food Fermentation : General Principles of cultures maintenance and preparation. Bacterial cultures, Yeast cultures and Mold cultures.
b. Food fermentations : Bread, Malt Beverages, Vinegar Fermented Vegetables, Fermented Dairy products, Oriental Fermented Food.
c. Foods and enzymes from Microorganism : Microorganisms as Food : Single cell protein, Fats from Microorganisms, Production of Amino acids, Production of other substances added to foods, Production of Enzymes.
3. Contamination, Spoilage and Preservation of different kinds of foods :
Cereals and Cereals products, Vegetables and Fruits, Fish and other, Sea foods, Poultry, Milik and Milk products, Canned foods.
4. Food borne disease and food safety :
Food borne infection and intoxication, Investigation of food borne disease outbreak :
Objectives of investigation, Personnel, Materials and Equipment for investigation, Laboratory testing and Interpretation of result, Preventive measures.
5. GM foods, Food security and General ethical concern : Food produced using modern biotechnology, Impacts of GM foods on human health and environment, The challenges to food security, Attaining food security, Globalization and market access of GM foods, Public perception, Labeling of GM foods and consumer choice.
Pharmaceutical biotechnology :
1. Introduction to biopharmaceuticals : Biotechnology versus Pharmaceutical biotechnology, Historical perspective of pharmaceutical biotechnology, Traditional pharmaceuticals of biological origin : Pharmaceuticals of animal, Plant and microbial origin. Pharmacokinetics.
2. Drug development : Drug discovery, impact of genomics, Proteomics and related technologies upon drug discovery ; Transforming new molecular entities into drug, Application of biotechnologies in drug development ; Biologic drug development and approval : pre-clinical and clinical trails ;
3. Therapeutics based on biotechnology : Interferons, Hormones, Enzymes, Antibiotics, Vaccines, Adjuvant technology, Blood products, Nucleic acid therapies.
4. Advanced drug delivery : Basic principles ; Controlled and sustained release : Polymer-based drug carriers, Lipid-membrane-based drug carriers : Permeation enhancement ; Molecular approaches of drug delivery.
5. Integration of pharmacokinteics and Pharmacogenetics : Historical perspective Metabolism and transport, Therapeutic response.
References :
1. Principle of fermentation technology – P.F. Stanbury Whitaker
2. Fermentation : a practical approach – B. McNeil and Harvey, IRL Press, Oxford.
3. Preseott & Dunn’s Industrial Microbiology - Gerald Reed
4. Food microbiology – W.C. Frazier and D.C. Westhoff
5. Biotechnology, Bol. 9. H.J. Rehm and G. Reed
6. Codex Alimentarius commission. Principles for the risk analysis of foods derived from modern biotechnology. FAO/WHO, Rome, 2003.
7. Biopharmaceuticals ; Biochemistry and Biotechnology by Gary Walsh
8. Biotechnology and Biopharmaceuticals by Rodney J.Y. Ho and Milo Gibaldi.
9. Pharmaceutical Microbiology by Hugo and Russel
10. Basic Biotechnology - Edited by John Bulock and Bjorn Kristiansen.
GEB 505 : Environmental and Agricultural Biotechnology (4 credits)
A. Environmental Biotechnology
1. Introduction to ecology and ecosystem.
2. Stoichiometry, kinetics and thermodynamics of microbial processes for the transformation of environmental contaminants, Design of dispersen growth and biofilm-based processes.
3. Environmental Influences on Microbial Activity : Temperature, pH, Water activity Redox potential, Inorganic nutrients.
4. Biotechnology of the marine environment : Pharmaceuticals, Molecular Biology product, Polymers, Enzymes and transgenic organisms, Micro algae and Marine pollution.
5. Solid waste management : landfills, composting, earthworm treatment, recycling and processing of organic residues. Wasteland : Uses and management, bioremediation and biorestoration of contaminated lands. Natural resource recovery : Oil recovery, Recovery of metals.
6. Biofuels : Fossil fuels – Supply and Emissions, remediation of the Emissions, Greenhouse gases and their natural resources, Biological energy sources, Ozone, sulphur dioxide, Biogas, Biodiesel, ethanol, hydrogen, combustion of biomass.
7. Drinking water treatment : Aerobic Biofilm processes to eliminate Biological instability, Release of micro-organisms, Biodegradation of organic compounds, Denitrification.
B. Agricultural Biotechnology
1. Production of disease free plants : shoot-tip-cultures, shoot-tip-grafting, viricidal compounds, Plant cell cultures for the production on useful chemicals : pigments perfumes, flavours, insecticides, anticancer agents and pharmacologically important compounds.
2. Molecular biology of nitrogen fixation, nif-gene transfer, herbicide resistance and stress tolerance in plants.
3. Transgenic Plants analysis and expression (DNA Analysis)
• Insect resistance, * Abiotic stress, * Herbicide tolerance, * Virus resistance * Adaptation to soil salinity and drought * Biopharming, * Value-added traits.
4. Protoplast isolation, culture and fusion, selection of hybrid cells and regeneration of hybrid plants, somatic hybridization and cybridization.
5. Isolation and characterization of organelle genome (Plastome and Chondriosome), Preservation of rare plant species germplasm collection and conservation.
6. Molecular Breeding : Plants & Animals (Molecular Markers for Breeding)
7. Fish Biotechnology
* History of aquaculture and associated fish breeding and selection
* Methods and goals for producing GM fish-examples and what is on the horizon
* Environmental and regulatory safety assessments of new fish varieties produced via GM and conventional means
8. Edible vaccines and its application.
Reference:
1. Comprehensive Biotechnology (Vol. 1-4) : M.Y. Yourng (Eds.), Pergamon Press, Oxford.
2. Environmental Microbiology : W.D. Grant & P.E. Long, Blakle, Glassgow and London.
3. Microbial Gene Technology : H. Polasa (ED.) South Asian Publishers, New Delhi.
4. Environmental Biotechnology : Principles and Application, by Bruce Rittmann and Perry McCarty.
5. Environmental Biotechnology : Alan Scargg, OXFORD international Press, 2nd edn.
6. Molecular Biotechnology : Principles & Application of Recombinant DNA. Glick & Pasternick – Required New 3rd edition.
7. Molecular Biotechnology, Primose-Reference (Previous Text)
8. Culture of Animals Cells : A manual of Basic Techniques, Freshney - Reference.
9. Genome Organization and Expression in Plants : C.J. Lever, plenum pres
10. Plant Molecular biology : D. Grierson & S.N. Covey Blackie, London.
11. Transgenic Plants Vol. 1 & 2 : S-d, Kund agn R. Wu (1993), Academic Press, San Diego
12. Plant Tissue Culture : Application and Limitations, S.S. Bhojwani (1990), Elsevier, Amsterdam.
13. Plant biotechnology in Agriculture : K. Lindsey and M.G.K. Joners (1990), Prentice Hall, New Jersey.
14. Fish genetics and aquaculture biotechnology by T.J. Pandian, CA Strussmann MP Marjan, Publisher : Enfield, (NH) : Science Publishers, 2005.
GEB 506 : Business Perspectives of Biotechnology (4 credits)
1. Business management : The Company, its environment, stakeholders, Corporate Strategies Some Basic economic principles (e.g. Profit maximization shareholder Value). Business planning and Decision making processes and supporting tools. Methods of business analysis, Introduction into Technology Development, Introduction into Procurement, Introduction into Operations management, Introduction into Procurement Introduction into Operations management, Introduction into Marketing/Sales.
2. Project management : Fundamentals of Project Management, the life cycle of a project ; (Project definition ; project planning ; project execution and controlling ; project close out), Tools and methods of project management (e.g. planning methods ; problem solving methods, Social competence in Project Management (teamwork ; communication)
3. Cost accounting and management : Basics of cost accounting, Structure of cost accounting Approaches of cost accounting.
4. Price Estimation : Cost estimates, Process design, Design exercise, Marginal cost, Marginal Revenue Determining cost of capital.
5. Basic Issues in planning and credit : Current Challenges, Structure of today’s Controlling.
6. Multidimensional Controlling : Time and quality-based Controlling, Auditing.
7. Practical applicaticates of business biotechnology : Biotechnology used for Biotechnological companies-their care and nurturing investment in biotechnology, management needs.
8. The Biotechnology Industry : Environmental Release of Genetically Modified Organisms ; Product Labeling, Technology Transfer ; Health Insurance and Reimbursement ; Entrepreneurship, Venture Capital, and the Life Cycle of a Biotechnology Company ; Public Perceptions of Biotech Products ; The Global Marketplace for Biotechnology Products.
9. Commercialization, Marketing Management of Biotechnological Products : Fundamentals of marketing and selling of Biotechnology. Creating and Marketing the image of the biotechnology Company, Power and importance of Positioning of a company name and product, The Art of Negotiation. Workable marketing and the strength of distribution, Effective advertising and marketing, Opportunities of international, marketing and lessons to be learnt, Steps involved in commercialization of a biotechnological product.
10. Intellectual Property Rights in Biotechnology :
a. Introduction : General Introduction, Patent Claims, The Legal Decision-Making Process, Ownership of intellectual Property
b. Basic Requirements of Patentability : Patentable Subject Matter, Novelty and the Public Domain.
c. Special Issue in Biotechnology Patents : Disclosure Requirements, Collaborative Research, Competitive Research, Foreign Patents.
d. Patent Litigation : Substantive Aspects of patent Litigation, Procedural Aspects of patent Litigation, and Recent Developments in patent System and Patentability of Biotechnological invention.
Reference:
1. Basic Biotechnology by Colin Ratledge (seminar copy)
2. Harold Koontz heint Wiehrich, management, McGraw-Hill book company, New York (USA)
3. P. Chanda. Project : Preparation, Appraisal, Budgeting and Implementation, Tata-McGraw-Hill, Publishing Company LTD, New Delhi India.
4. R.J. Ruffin and P.R. Gregary, Principles of Microeconomics, Scott Foreguson and company, illinosis.
5. Introduction to Biotechnology by William J. Thieman and Michael A. Palladino. 2004. Pearson Education/Benjamin Cummings, San Francisco CA. ISBN 0-8053-4825-5.
6. The ethical dimensions of the biological sciences. Edited by Ruth Ellen Bulger et al. NY : Cambridge University Press. 1993.
7. The coming biotech age : The business of biomaterials. By Richard Oliver. NY : McGraw Hill 2000.
GEB 507 : Seminar (2 credits)
In this course each student will have to present a full paper that has been published in an international journal (approved by the departmental academic committee).