Dr. Md. Anwarul Azim Akhand

1. Ali M. S. and Akhand A. A. (1992). Cellulose from Trichoderma isolate. J. Basic Microbiol. 32, 259-268.

2. Ali M. S, Akhand A. A., Gomez P. F. and Islam R. I. (1993). Cellulase from Humicola spp. J. Basic Microbiol. 33, 155-159.

3. Katano Y., Pu M., Akhand A. A., Hamaguchi M., Koga Y., Isobe K. Fukuda Y., Hayakawa T. and Nakashima I. (1995). Evidence of redox-linked signaling for producing a giant signal complex. J. Cell. Biochem. 57, 432-439.

4. Ma L., Pu M., Yi H., Akhand A. A., Ohata N., Ohkusu K., Kato M., Iwamoto T., Isobe K., Hamaguchi M. and Nakashima I. (1995). Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent. J. Cell Biochem. 59, 33-41.

5. Pu M., Akhand A. A., Kato M., Koike T., Hamaguchi M., Suzuki H. and Nakashima I. (1996). Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine. J. Cell. Biochem. 63, 104-114.

6. Pu M., Akhand A. A., Kato M., Hamaguchi M., Koike T., Iwata H., Sabe H., Suzuki H. and Nakashima I. (1996). Evidence of a novel redox linked activation mechanism for the Src Kinase which is independent of tyrosine 527-mediated regulation. Oncogene, 13, 2615-2622.

7. Akhand A. A., Pu M., Du J., Kato M., Suzuki H., Hamaguchi M. and Nakashima I (1997). Magnitude of protein tyrosine phosphorylation-linked signal determines growth versus death of thymic T lymphocytes Eur. J. Immunol. 27, 1254-1259.

8. Nakashima I., Pu M., Akhand A. A., Kato M. and Suzuki H. (1997). Chemical events in signal transduction (Letter). Immunol. Today. 18, 362.

9. Nakashima I., Pu M., Akhand A. A., and Kato M. (1997). Sulfhydryl-based regulation of Src family protein tyrosine kinase for cell growth and death. In Proceedings of the Jakarta International Cancer Conference, editd by Berkel H, Faculty Medicine University Press, Jakarta. pp231-240.

10. Ohkusu K., Du J., Isobe K., Yi H., Akhand A. A., Kato M., Suzuki H., Hidaka H., and Nakashima I. (1997). Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL- lpr/lpr mice, Eur. J. Immunol. 25, 3180-3186.

11. Liu ., Kato M., Akhand A. A., Hayakawa A., Takemura M., Yoshida S. Suzuki H. and Nakashima I. (1998). The herbal medicine sho-saiko-to inhibits the growth of malignant cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulating of cyclin dependent kinase. Int. J. Oncol.

12, 1321-1326. 12. Akhand A. A., Kato M., Suzuki H., Miyata T. and Nakashima I. (1998). Level of Hgcl2-mediated phosphorylation of intracellular proteins determines death of thymic T lymphocytes with or without DNA fragmentation. J. Cell. Biochem. 71, 243-253.

13. Kato M., Takahashi M., Akhand A. A., Liu W., Dai Y., Shimizu S., Iwamoto T., Suzuki H. and Nakashima I. (1998). Transgenic mouse model for skin malignant melanoma. Oncogene. 17, 1885-1888.

14. Parashar A., Akhand A. A., Rawar R., Furuno T., Nakanishi M., Kato M., Suzuki H. and Nakashima I. (1999). Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phosphorylation-linked mechanism. Free Rad. Biol. & Med. 26, 227-231.

15. Akhand A. A., Kato M., Suzuki H., Liu W., Du J., Hamaguchi M., Miyata T., Kurokawa K. and Nakashima I. (1999). Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src. J. Cell. Biochem. 72, 1-7.

16. Kato M., Liu W., Akhand A. A., Dai Y., Ohbayashi M., Suzuki H., Isobe K., Takahashi M. and Nakashima I. (1999). Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines. Oncogene. 18, 837-842.

17. Nakashima I., Akhand A. A., Pu M., Kato M., Hamaguchi M., Senga T., Suzuki H., Parashar A., Du J. and Liu W, Umeda Y and Miyata T. (1999). Redox-oriented chemical events in signal transduction in cells. In Redox Regulation of Cell Signaling and its Clinical Application (Eds. L. Packer and J. Yodoi). Marcel Dekker, Inc., New York. Pp 177-204.

18. Liu W., Akhand A. A., Kato M., Yokoyama I., Uchida K., Miyata T., Kurokawa K. and Nakashima I. (1999). 4-Hydroxynonenal triggers epidermal growth factor receptor-linked signal pathway for growth inhibition. J. Cell Sci. 112. 2409-2417.

19. Akhand A. A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M. and Nakashima I. (1999). Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr527-independent and Tyr416-linked mechanism. J. Biol. Chem. 274, 25821- 25826.

20. Kato M., Iwashita T., Takeda K., Akhand A. A., Liu W., Yoshihara M. Asai N., Suzuki H. and Nakashima I. (2000). Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases. Mol. Biol. Cell. 11, 93-101.

21. Liu W., Kato M., Akhand A. A., Hotta Y., Ishikawa N., Hayakawa A., Suzuki H., Miyata T., Kurokawa K and Nakashima I. (2000). 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J. Cell Sci. 113, 635-641.

22. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., Miyata T., Kurokawa K., and Nakashima I (2000). Methylglyoxal induces apoptosis in Jurkat leukemia T-cells by activating c-Jun N-terminal kinase. J. Cell. Biochem. 77, 333-344.

23. Nakashima I., Akhand A. A., Kato M., Du J., Liu W., Hossain K., Suzuki H., Wu J., Takeda K., and Yoshihara M. (1999). Oxidative stress and signal transduction in the immune system. Recent Res. Devel. Immunol. 1, 283-296.

24. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., and Nakashima I. (2000). Mercuric chloride stimulates distinct signal transduction pathways for DNA synthesis in a T cell line. CTLL-2. J. Cell. Biochem. 78, 500-508.

25. Kato M., Iwashita T., Akhand A. A., Liu W., Takeda K., Takeuchi K, Yoshihara M., Hossain K., Wu J., Oh C., Fujitani S., Shimuzu Y., Sobajima Y., Takahashi M. and Nakashima I. (2000). Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation. Antioxidants and Redox Signal. 2, 841-849.

26. Hossain K., Akhand A. A., Kato M., Du J., Takeda K., Wu J., Takeuchi K., Liu W., Suzuki H. and Nakashima I. (2000). Arsenite induces apoptosis of murine T lymphocytes through membrane rafts-linked signaling for activation of c-Jun amino terminal kinase (JNK). J. Immunol. 165, 4290-4297.

27. Nakashima I., Kato M., Akhand A. A., Du J., Liu W., Dai Y., Suzuki H., Senga T., Hamaguchi M., Iwashita T., Takahashi M., Miyata T., Hossain K., Wu J., Takeuchi K., Yoshihara M. and Kawamoto Y. (2000). Chemical reaction-mediated alternative signaling pathway in cells of the immune system. Curr. Trends Immunol. 3, 45-58.

28. Kato M., Liu W., Akhand A. A., Hossain K., Takeda K., Takahashi M. and Nakashima I (2000). Ultraviolet radiation induces both full activation of Ret kinase and malignant melanocyte tumor promotion in RFP-RET-transgenic mice. J. Invest. Dermatol. 115, 1157-1158.

29. Takeuchi K., Kato M., Suzuki H., Akhand A. A., Wu J., Hossain K., Miyata T., Matsumoto Y., and Nakashima I. (2001). Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death. J. Cell. Biochem. 81, 679-688.

30. Akhand A. A., Hossain K., Mitsui H., Kato M., Miyata T., Inagi R., Du J., Takeda K., Kawamoto Y., Suzuki H., Kurokawa K., Nakashima I. (2001). Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells. Free Radic. Biol. Med. 31, 20-30.

31. Miyata T., Akhand A. A., Kurokawa K., Nakashima I. (2001). Reactive carbonyl compounds as uremic toxins. Contrib. Nephrol. 133, 71-80.

32. Wu J., Suzuki H., Zhou Y., Liu W., Yoshihara M., Akhand A. A., Hayakawa A., Takeuchi K., Hossain K., Kurosawa M., and Nakashima I. (2001). Cepharanthene activates caspase and induces apoptosis in Jurkat and K562 human leukemia cell lines. J. Cell. Biochem. 82, 200-214.

33. Du J., Suzuki H., Nagase F., Akhand A. A., Ma X-Y., Yokoyama T., Miyata T., and Nakashima I. (2001). Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic. Biol. Med. 31, 469-478.

34. Dai Y., Kato M., Takeda K., Kawamoto Y., Akhand A. A., Hossain K., Suzuki H., and Nakashima I. (2001). T-cell immunity-based inhibitory effects of orally administered herbal medicine Juzen-taiho-to on the growth of primarily developed melanocytic tumors in Ret-transgenic mice. J. Invest. Dermatol. 117, 694-701.

35. Akhand A. A., Hossain K., Kato M., Miyata T., Du J., Suzuki H., Kurokawa K., and Nakashima I. (2001). Glyoxal and methylglyoxal induce aggregation and inactivation of ERK in human endothelial cells. Free Radic. Biol. Med. 31, 1228-1235.

36. Wu J., Suzuki H., Akhand A. A., Zhou Y., Hossain K., and Nakashima I. (2002). Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells. Cell Signal. 14, 509-515.

37. Kato M., Takeda K., Kawamoto Y., Iwashita T., Akhand A. A., Senga T., Yamamoto M., Sobue G., Hamaguchi M., Takahashi M. and Nakashima I. (2002). Repair by Src kinase of function-impaired RET with multiple endorcrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res. 62, 2414-2422.

38. Nakashima I., Suzuki H., Kato M. and Akhand A. A. (2002). Redox control of T-cell death. Antioxid. Redox Signal. 4, 353-356.

39. Nakashima I., Kato M., Akhand A. A., Suzuki H., Takeda K., Hossain K., and Kawamoto Y. (2002). Redox-linked signal transduction pathways for protein tyrosine kinase activation. Antioxid. and Redox Signal. 4, 517-531.

40. Akhand A. A., Du J., Liu W., Hossain K., Miyata T., Nagase F., Kato M., Suzuki H., and Nakashima I. (2002). Redox-linked cell surface-oriented signaling for T-cell death. Antioxid. and Redox Signal., 4, 445-454.

41. Akhand A. A., Ikeyama T., Akazawa S., Kato M., Hossain K., Takeda K., Suzuki H., Takahashi M., and Nakashima I. (2002). Evidence of both extra and intracelluar cysteine targets of protein modification for activation of Ret kinase. Biochem. Biophys. Res. Com. 292, 826-831.

42. Ruhul Amin A. R., Machida K., Oshima K., Oo M. L., Thant A. A., Senga T., Matsuda S., Akhand A. A., Maeda A., Kurosaki T. and Hamaguchi M. (2002). A role for SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling. Oncogene. 21, 8871-8878.

43. Hossain K., Akhand A. A., Kawamoto Y., Du J., Takeda K., Wu J., Yoshihara M., Tsuboi H., Kato M., Suzuki H. and Nakashima I. (2003). Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. Free Radic. Biol. Med. 34, 598-606.

44. Du J., Cai S., Akhand A. A., Ma X., Tagaki Y., Miyata T., Nakashima I. and Nagase F. (2003). Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. J. Cell. Biochem. 88, 1235-1246.

45. Liu W., Akhand A. A., Takeda K., Kawamoto Y., Itoigawa M., Kato M., Suzuki H. Ishikawa N., and Nakashima I. (2003).Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal.Cell Death Differ. 10, 772-781.

46. Nakashima I. Liu W., Akhand A. A., Takeda K., Kawamoto Y., Kato M. and Suzuki H. (2003). 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Mol Aspects Med. 24, 231-238.

47. Suzuki H., Wu J., Hossain K. Ohhata T., Du J., Akhand A. A., Hayakawa A., Kimura H., Hagiwara M., and Nakashima I. (2003). Involvement of MKK6 in TCRαβintCD69lo: a target population for apoptotic cell death in thymocytes. FASEB J. 17, 1538-1540.

48. Kajiguchi T., Yamamoto K., Hossain K., Akhand A. A., Nakashima I., Naoe T., Saito S. and Emi N. (2003). Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1. Leukemia. 17, 2189-2195.

49. Tsuboi H., Hossain K., Akhand A. A., Takeda K., Du J., Rifai M, Dai Y., Hayakawa A., Suzuki H. and Nakashima I. (2004) Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J Cell Biochem. 93, 162-172.

50. Ahmed M., Nazneen S. and Akhand A. A. (2006) Molecular analysis of hepatitis B virus DNA and mutation status in patients under lamivudine [(-) 2’ 3’-dideoxy-3’ thiacytidine] therapy. Dhaka Univ J Pharm Sci. 4(2), 19-23.

51. Ahsan N and Akhand A. A. (2008) Latent membrane protein 1 (LMP1) of akara strain of Epstein-Barr virus is essential for B cell transformation. Bangladesh J Med Sci. 14 (2), 112-116.

52. Akter M. S., Ahmed M. K., Akhand A. A. and Islam M. M. (2008) Acute toxicity of Arsenic and mercury to fresh water climbing perch, Anabas testudineus (Bloch). World J Zool. 3(1), 13-18.

53. Ahmed M.K., Akhand A. A., Hasan M., Islam M. and Hasan A. (2008) Toxicity of arsenic (sodium arsenite) to fresh water spotted snakehead Channa punctatus (Bloch) on cellular death and DNA content. American-Eurasian J Agric & Environ Sci. 4(1), 18-22.

54. Perveen S., Ahsan N. and Akhand A. A. (2008) Influence of temperature and growth regulators on wound periderm formation of potato tuber. Mol Biol & Biotechnol J. (in press)

55. Akter M. S., Ahmed M. K., Akhand A. A., Ahsan N., Islam M. M. and Khan M. S. (2009). Arsenic and Mercury Induce Death of Anabas testudineus (Bloch) Involving Fragmentation of Chromosomal DNA. Terrestrial & Aquatic Environ Toxicol. 3(1), 42-47.

56. Chowdhury M. K., Ahsan N. and Akhand A. A. (2009). Comparative antibacterial effects of leaf extracts of Azadirachta indica and Terminalia arjuna and aggregation of bacterial proteins. J Trop Med Plants. 10(1), 31-38.

57. Chowdhury M. K., Ahsan N. and Akhand A. A. (2009). Leaf extracts of Azadirachta indica and Terminalia arjuna induce death of HeLa cells without DNA degradation. Dhaka Univ J Pham Sci. 8(1), 75-79.

58. Hossain K., Kawamoto Y., Akhand A. A., Yanagishita T., Hoque A., Tsuboi H., Kato M., and Nakashima I. (2009). 1,4-butanediyl-bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells. (2009). J. Cell. Biochem. (in press).

59. Hasan A., Ahmed M.K., Akhand A. A., Ahsan N., Islam M. (2009) Toxicological Effects and Molecular Changes Due to Mercury Toxicity in Freshwater Snakehead (Channa punctatus Bloch, 1973). Int. J. Environ. Res. (in press).