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3.July 2002 until todate: Asst.Professor, Department of Genetic Engineering and Biotechnology, University of Dhaka
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Training Course
Participated in the UNESCO/ICRO (International Cell Research Org.) International Training Course from July 4 to July 15, 1994 on "Basic Procedures for Medical Virology" organized by Nagoya University School of Medicine, Japan.
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Academic Award
1. Obtained the "Dean's Honour List Certificate" from the faculty of Biological Sciences, Dhaka University, Dhaka for outstanding performance in the B. Sc. Honours Course.

2. Obtained the scholarship of Ministry of Education, Science, Sports and Culture of Japan (Monbusho) for the PhD. course.
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Professional Society
1. Member of the Japanese Society for Immunology
2. Member of the Japanese Universities Alumni Association in Bangladesh
3. Member of the Graduate Biochemists Association of Bangladesh
4. Member of the Bangladesh Society for Biochemistry and Molecular Biology

Editorial Board Membership
Member of the editorial board of The Dhaka University Journal of Biological Sciences

Other Activities
· Student advisor, Department of Genetic Engineering & Biotechnology, DU
· Assistant House Tutor, Fazlul Huq Hall, DU.
 

Technical Skills

Cell Biology: Tissue culture techniques for primary and established cell lines, and cell lines expressing stably transfecting genes.

Immunology: Working knowledge of monoclonal/polyclonal antibody development (immunization of mice/rabbit, production and maintenance of hybridomas, screening of hybridoma cultures), immunoblotting and immune precipitation of cell lysates, fluorescence antibody technique and FACS (fluoresceine-activated cell sorter) analysis.

Biochemistry: SDS-PAGE, in vivo and in vitro kinase assay, phosphoamio acid analysis of peptides, cyanogn bromide cleavage mapping of peptides, kinetic measurement of Km and Vmax of enzymes, agarose gl electrophoresis, TUNEL assay for determining apoptosis, [3H]thymidine uptake assay
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List of Publications

1. Ali M. S. Akhand A. A. (1992) Cellulose from Trichoderma isolate. J. Basic Microbiol. 32, 259-268.
2. Ali M. S. Akhand A. A., Gomez P. F. and Islam r. i. (1993) Cellulase from Humicola spp. J. Basic Microbiol. 33, 155-159.
3. Katano Y. Pu M., Akhand A. A., Hamaguchi M., Koga Y., Isobe K. Fukuda Y., Hayakawa T. and Nakashima I. (1995) Evidence of redox-linked signaling for producing a giant signal complex. J. Cell. Biochem. 57, 432-439.
4. Ma L. Pu M., Yi H., Akhand A. A. Ohata N., Ohkusu K., Kato M., Iwamoto T., Isobe K., Hamaguchi M. and Nakashima I. (1995) Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent. J. Cell Biochem. 59, 33-41.
5. Pu M., Akhand A. A., Kato M., Koike T., Hamaguchi M., Suzuki H. and Nakashima I. (1996) Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine. J. Cell. Biochem. 63, 104-114.

6. Pu M., Akhand A. A. Kato M., Hamaguchi M., Koike T., Iwata H., Sabe H., Suzuki H. and Nakashima I. (1996) Evidence of a novel redox linked activation mechanism for the Src Kinase which is independent of tyrosine 527-mediated regulation. Oncogene, 13, 2615-2622.
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7. Akhand A. A., Pu M., Du J., Kato M., Suzuki H., Hamaguchi M. and Nakashima I . (1997) Magnitude of protein tyrosine phosphorylation-linked signal determines growth versus death of thymic T lymphocytes Eur. J . Immunol. 27, 1254-1259.

8. Nakashima I., Pu M., Akhand A. A., Kato M. and Suzuki H. (1997) Chemical events in signal transduction (Letter). Immunol. Today. 18, 362.

9. Nakashima I., Pu M., Akhand A. A., and Kato M. (1997) Sulfhydryl-based regulation of Src family protein tyrosine kinase for cell growth and death. In Proceedings of the Jakarta International Cancer Conference, editd by Berkel H, Faculty Medicine University Press, Jakarta. pp231-240.

10. Ohkusu K., Du J., Isobe K., Yi H., Akhand A. A., Kato M., Suzuki H., Hidaka H., and Nakashima I. (1997), Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL- lpr/lpr mice, Eur. J. Immunol. 25, 3180-3186.

11. Liu ., Kato M., Akhand A. A., Hayakawa A., Takemura M., Yoshida S. Suzuki H. and Nakashima I. (1998). The herbal medicine sho-saiko-to inhibits the growth of malignant cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulating of cyclin dependent kinase. Int. J. Oncol. 12, 1321-1326.

12. Akhand A. A., Kato M., Suzuki H., Miyata T. and Nakashima I. (1998). Level of Hgcl2-mediated phosphorylation of intracellular proteins determines death of thymic T lymphocytes with or without DNA fragmentation. J. Cell. Biochem. 71, 243-253.
 

13. Kato M., Takahashi M., Akhand A. Liu W., Dai Y., Shimizu S., Iwamoto T., Suzuki H. and Nakashima I. (1998) Transgenic mouse model for skin malignant melanoma. Oncogene. 17, 1885-1888.
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14. Parashar A., Akhand A. A., Rawar R., Furuno T., Nakanishi M., Kato M., Suzuki H. and Nakashima I. (1999). Mercuric Chloride Induces Increases in both Cytoplasmic and Nuclear Free Calcium Ions through a Protein Phosphorylation-Linked Mechanism. Free Rad. Biol. & Med. 26,227-231.
 

15. Akhand A. A., Kato M., Suzuki H., Liu Wei L., Du J., Hamaguchi M., Miyata T.,Kurokawa k. and Nakashima I. (1999). Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src. J. Cell. Biochem. 72, 1-7.

16. Kato M., Liu W., Akhand A. A., Dai Y., Ohbayashi M., Suzuki H., Isobe K., Takahashi M. and Nakashima I. (1999). Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines. Oncogene. 18, 837-842.

17. Nakashima I., Akhand A. A., Pu M., Kato M., Hamaguchi M., Senga T., Suzuki H., Parashar A., Du J. and Liu W, Umeda Y and Miyata T. (1999). Redox-oriented chemical events in signal transduction in cells. In Redox Regulation of Cell Signaling and its Clinical Application (Eds. L. Packer and J. Yodoi). Marcel Dekker, Inc., New York. Pp 177-204.
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18. Liu W., Akhand A. A., Kato M., yokoyama I., Uchida K., Miyata T., Kurokawa K. and Nakashima I. (1999). 4-Hydroxynonenal triggers epidermal growth factor receptor-linked signal pathway for growth inhibition. J. Cell Sci. 112. 2409-2417.
 

19. Akhand A. A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M. and Nakashima I. (1999). Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr527-independent and Tyr416-linked mechanism. J. Biol. Chem. 274, 25821- 25826.

20. Kato M., Iwashita T., Takeda K., Akhand A. A., Liu W., Yoshihara M. Asai N., Suzuki H. and Nakashima I. (2000). Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases. Mol. Biol. Cell. 11, 93-101.

21. Liu W., Kato M., Akhand A. A., Hotta Y., Ishikawa N., Hayakawa A., Suzuki H., Miyata T., Kurokawa K and Nakashima I. (2000). 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J. Cell Sci. 113, 635-641.
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22. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., Miyata T., Kurokawa K., and Nakashima I (2000). Methylglyoxal Induces Apoptosis in Jurkat Leukemia T-cells by Activating c-Jun N-terminal Kinase. J. Cell. Biochem. 77, 333-344.

23. Nakashima I., Akhand A. A., Kato M., Du J., Liu W., Hossain K., Suzuki H., Wu J., Takeda K., and Yoshihara M. (19990. oxidative stress and signal transduction in the immune system. Recent Res. Devel. Immunol. 1, 283-296.
 

24. Du J., Suzuki H., Nagase F., Akhand A. A., Yokoyama T., and Nakashima I. (2000). Mercuric chloride stimulates distinct signal transduction pathways for DNA synthesis in a T cell line. CTLL-2. J. Cell. Biochem. 78, 500-508.

25. Kato M., Iwashita T., Akhand A. A., Liu W., Takeda K., Takeuchi K, Yoshihara M., Hossain K., Wu J., Oh C., Fujitani S., Shimuzu Y., Sobajima Y., Takahashi M. and Nakashima I. (2000). Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation. Antioxidants and Redox Signal. 2, 841-849.

26. Hossain K., Akhand A. A., Kato M., Du J., Takeda K., Wu J., Takeuchi K., Liu W., Suzuki H. and Nakashima I. (2000). Arsenite Induces Apoptosis of Murine T Lymphocytes Through Membrane Rafts-Linked Signaling for Activation of c-Jun Amino Terminal Kinase (JNK). J. Immunol. 165, 4290-4297.
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27. Nakashima I., Kato M., Akhand A. A., Du J., Liu W., Dai Y., Suzuki H., Senga T., Hamaguchi M., Iwashita T., Takahashi M., Miyata T., Hossain K., Wu J., Takeuchi K., Yoshihara M. and Kawamoto Y. (2000). Chemical reaction-mediated alternative signaling pathway in cells of the immune system. Curr. Trends Immunol 3, 45-58.

28. Kato M., Liu W., Akhand A. A., Hossain K., Takeda K., Takahashi M. and Nakashima I (2000). Ultraviolet radiation induces both full activation of Ret kinase and malignant melanocyte tumor promotion in RFP-RET-transgenic mice. J. Invest. Dermatol. 115, 1157-1158.
 

29. Takeuchi K., Kato M., Suzuki H., Akhand A. A., Wu J., Hossain K., Miyata T., Matsumoto Y., and Nakashima I. (2000). Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death J. Cell. Biochem. 81, 679-688.

30. Akhand A. A., Hossain K., Mitsui H., Kato M., Miyata T., Inagi R., Du J., Takeda K., Kawamoto Y., Suzuki H., Kurokawa K., Nakashima I. (2000). Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells. Free Radic Biol Med. 31, 20-30.
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31. Miyata T., Akhand A. A., Kurokawa K., Nakashima I. (2000) Reactive carbonyl compounds as uremic toxins. Contrib Nephrol. 133, 71-80.

32. Wu J., Suzuki H., Zhou Y., Liu W., Yoshihara M., Akhand A. A., Hayakawa A., Takeuchi K., Hossain K., Kurosawa M., and Nakashima I. (2000). Cepharanthene activates caspase and induces apoptosis in Jurkat and K562 human leukemia cell lines. J. Cell. Biochem. 82, 200-214.

33. Du J., Suzuki H., Nagase F., Akhand A. A., Ma X-Y., Yokoyama T., Miyata T., and Nakashima I. 2000. Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic Biol Med. 31, 469-478.

34. Dai Y., Kato M., Takeda K., Kawamoto Y., Akhand A. A., Hossain K., Suzuki H., and Nakashima I. (2001). T-cell immunity-based inhibitory effects of orally administered herbal medicine Juzen-taiho-to on the growth of primarily developed melanocytic tumors in Ret-transgenic mice. J. Invest. Dermatol. 117, 694-701.
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35. Akhand A. A., Hossain K., Kato M., Miyata T., Du J., Suzuki H., Kurokawa K., and Nakashima I. (2001). Glyoxal and methylglyoxal induce aggregation and inactivation of ERK in human endothelial cells. Free Radic Biol Med. 31, 1228-1235.

36. Wu J., Suzuki H., Akhand AA., Zhou Y., Hossain K., and Nakashima I. (2002). Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells. Cell Signal. 14, 509-515.

37. Kato M., Takeda K., Kawamoto Y., Iwashita T., Akhand A. A., Senga T., Yamamoto M., Sobue G., Hamaguchi M., Takahashi M. and Nakashima I. (2002). Repair by Src kinase of function-impaired RET with multiple endorcrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res. 62, 2414-2422.

38. Nakashima I., Suzuki H., Kato M. and Akhand A. A. (2002) Redox control of T-cell death. Antioxide. Redox Signal. 4, 353-356.

39. Nakashima I., Kato M., Akhand A. A., Suzuki H., Takeda K., Hossain K., and Kawamoto Y.(2002) Redox-linked signal transduction pathways for protein tyrosine kinase activation. Antioxdants and Redox Signal. 4, 517-531.

40. Akhand A. A., Du J., Liu W., Hossain K., Miyata T., Nagase F., Kato M., Suzuki H., and Nakashima I. (2002) Redox-linked cell surface-oriented signaling for T-cell death. Antioxidants and Redox Signal, 4, 445-454.

41. Akhand A. A., Ikeyama T., Akazawa S., Kato M., Hossain K., Takeda K., Suzuki H., Takahashi M., and Nakashima I. Evidence of both extra and intracelluar cysteine targets of protein modification for activation of Ret kinase. Biochem. Biophys. Res. Com. 292, 826-831.

42. Ruhul Amin A. R., Machida K., Oshima K., Oo M. L., Thant A. A., Senga T., Matsuda S., Akhand A. A., Maeda A., Kurosaki T. and Hamaguchi M. (2002). A role for SHPS-1/SIRPa1 in IL-1ß- and TNFa-dependent signaling. Oncogene. 21, 8871-8878.

43. Hossain K., Akhand A. A., Kawamoto Y., Du J., Takeda K., Wu J., Yoshihara M., Tsuboi H., Kato M., Suzuki H. and Nakashima I. (2003). Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. Free Radic. Biol. Med. 34, 598-606.

44. Du J., Cai S., Akhand A. A., Ma X., Tagaki Y., Miyata T., Nakashima I. and Nagase F. (2003). Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. J. Cell. Biochem. 88, 1235-1246.

45. Liu W., Akhand A. A., Takeda K., Kawamoto Y., Itoigawa M., Kato M., Suzuki H. Ishikawa N., and Nakashima I. (2003).Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal.Cell Death Differ. 10, 772-781.

46. Nakashima I. Liu W., Akhand A. A., Takeda K., Kawamoto Y., Kato M. and Suzuki H. (2003). 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Mol Aspects Med. 24, 231-238.

47. Suzuki H., Wu J., Hossain K. Ohhata T., Du J., Akhand A. A., Hayakawa A., Kimura H., Hagiwara M., and Nakashima I. (2003). Involvement of MKK6 in TCRalphaßintCD69lo: a target population for apoptotic cell death in thymocytes. FASEB J. 17, 1538-1540.

48. Kajiguchi T., Yamamoto K., Hossain K., Akhand A. A., Nakashima I., Naoe T., Saito S. and Emi N. (2003). Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1. Leukemia. (17, 2189-2195).

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Presentation in Scientific Conferences
1. Attended the 23rd Annual Conference, 1993 of the Japanese Society for Immunology held in Sendai and participated in the poster session.
Akhand A. A., Idris R., Li M., Pu M., Hamaguchi M., Isobe K. and Nakashima I. (1993). Multiplicity of the redox-mechanism mediated control of lymphocyte signal transduction. Proc. Jpn. Soc. Immunol. Vol. 23, pp. 571. (abstract).
2. Ma L., Pu M., Hong I., Akhand A. A., Hamaguchi M., Isobe K. and Nakashima I. (1993). Acceleration by monoiodoacetic acid of a CD3 mAb-induced protein tyrosine phosphorylation in murine T lymphoeytes. Proc. Jpn. Soc. Immunol. Vol. 23.pp. 269. (abstract).

3. Attended the First International Conference on Redox and Signal Information, 1993 held in Kyoto.
Nakashima I., Katano Y., Hamaguchi M., Ohkusu K., Akhand A. A., Ohata T., and Yi H. (1993). Redox mechanism triggers a pathway for signaling through cell surface receptors. In the abstract book of The First Conference on Redox and Signal Information. Pp. 10. (abstract).
4. Attended the 24th Annual Conference, 1994 of the Japanese Society for Immunology held in Kyoto and participated in the workshop for presenting posters.
Akhand A. A., Yi H., Pu M., Ma L., Isobe K., Hamaguchi M. and Nakashima I. (1994). Characterization of the iodoacetic acid-modulated TCR-dependent signal for T-cell activation. Proc. Jpn. Soc. Immunol. Vol. 24, pp. 454, (abstract).
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5. Nakashima I., Pu M., Akhand A. A., Hayashi Y., Parashar A. and Isobe K. (1994). Evidence of complicated crosslinkage of cell surface receptors by thiol-reactive heavy metals for disregulated lymphocyte signaling. Proc. Jpn. Soc. Immunol. Vol. 24, pp. 186. (abstract)
6. Parashar A., Kato M., Ohkusu K., Pu M., Akhand A. A., Isobe K. and Nakashima I. (1994). Differential expression of DT - diphorage in normal mouse strains and tumor tissues; Its modulation with heat shock and heavy metals. Proc. Jpn. Soc. Immunol. Vol. 24, pp. 298, (abstract)
7. Attended the 9th International Congress of Immunology, 1995 held in San Francisco, USA and participated in the poster session.
Akhand A. A., Katano Y., Pu M., Isobe K., and Nakashima I. (1995). Characterization of the signal into T lymphocytes delivered by thiol-reactive heavy metals. The 9th International Congress of Immunology abstract book. Pp, 13. (abstract).
8. Nakashima I., Akhand A. A., Pu M., and Morita T. (1995). Membrane dynamics for a cysteine-oriented pathway of signal transduction into T lymphocytes. The 9th International Congress of Immunology abstract book. Pp, 13. (abstract).

9. Attended the 25th Annual Conference, 1995 of the Japanese Society for Immunology held in Fukuoka and participated in the poster session.
Akhand A. A., Hamaguchi M. and Nakashima I. (1995). Analysis of tyrosine phosphorylated proteins in T-lymphocytes exposed to Hg2+. Proc. Jpn. Soc. Immunol. Vol. 25, pp. 158. (abstract).
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10. Attended the 26th Annual Conference, 1996 of the Japanese Society for Immunology held in Yokohama and participated in the poster session.
Akhand A. A., Kato M., Suzuki H. and Nakashima I. (1996). Characterization of the HgCl2-induced signal into T-lymphocytes. Proc. Jpn. Soc. Immunol. Vol. 26. pp. 156. (abstract)
11. Attended the 27th Annual Conference, 1997 of the Japanese Society for Immunology held in Sapporo and participated in the workshop for presenting posters.
Akhand A. A., Kato M., Suzuki H. and Nakashima I. (1997). DNA fragmentation-linked and -unlinked cell death demonstrated in heavy metal-treated thymocytes. Proc. Jpn. Soc. Immunol. Vol. 27, pp. 319, (abstract).
12. Du J., Akhand A. A., Nagase F., Suzuki H., and Nakashima I. (1997). Characterization of low concentration Hg2+-induced signal transduction into T cell line CTLL-2. Proc. Jpn. Soc. Immunol. Vol. 27.pp, 319. (abstract).
13. Attended the 10th International Congress of Immunology, 1998 held in New Delhi, India and participated in the poster session.
Akhand A. A., Kato M., Suzuki H., Hamaguchi M., Miyata T., Kurokawa K. and Nakashima I (1998). Signal transduction into murine T lymphocytes and fibroblasts after chemical stimulation. The Immunologist (the 10th International Congress of Immunology abstract book). Pp, 391. (abstract).
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14. Attended the 28th Annual Conference, 1998 of the Japanese Society for Immunology held in Kobe and participated in the workshop for presenting posters.
Akhand A. A., Kato M., Suzuki H., Liu W., Du J., Hamaguchi M., Miyata T., Kurokawa K. and Nakashima I. Glyoxal cross-links cellular proteins and activates non-receptor protein-tyrosine kinases in T lymphocytes and fibroblasts. Proc. Jpn. Soc. Immunol. Vol. 28, pp. 196. (abstract).
15. Attended the "International Symposium for Oxidative Stress, Redox Regulation and Signal Transduction; Clinical Implication" held in Kyoto, Japan and participated in the poster session.
Akhand A. A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M. and Nakashima (1999), Nitric oxide controls Src kinase activity through a redox reaction-mediated Tyr527-independent and Tyr416-linked mechanism. Abstract book of the 'International Symposium for Oxidative Stress, Redox Regulation and Signal Transduction; Clinical Implication' pp. 72.
16. Attended the 29th Annual Conference, 1999 of the Japanese Society for Immunology held in Kyoto and participated in the workshop for presenting posters. Akhand A. A., Hossain K., Kato M., Du J., Suzuki H., Miyata T. and Nakashima I. Regulation of mitogen activated protein kinase (MAPK) family in human endothelial cells by carbonyl stress. Proc. Jpn.
Soc. Immunol. Vol. 29, pp. 38. (abstract).
 

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17. Hossain K., Akhand A. A., Kato M., Suzuki H., and Nakashima I. Mitogen activated protein kinase (MAPK)- and caspase-dependent apoptosis of murine thymocytes exposed to arsenicals. Proc. Jpn. Soc. Immunol. Vol. 29, pp. 345. (abstract).
18. Attened the 30th Annual Conference, 2000 of the Japanese Society for Immunology held in Sendai and participated in the workshop for presenting posters. Akhand A. A., Hossain K., Kato M., Du J., Takeda K., Suzuki H., Miyata T. and Nakashima I. Carbonyl compound-mediated signaling for MAP family kinases and caspase activation in human endothelial cells. Proc. Jpn. Soc. Immunol. Vol. 30, pp. 275. (abstract).

19. Hossain K., Akhand A. A., Kato M., Du J., Takeda K., Wu J., Tsuboi H., Suzuki H., and Nakashima I. Arsenic induces membrane-raft linked apoptotic signals in murine thymic Tlymphocytes. Proc. Jpn. Soc. Immunol, Vol. 30, pp. 272. (abstract).
20. Attended the 11th International Congress of Immunology, 2001 held in Stockholm, Sweden and participated in the poster session.
Akhand A. A., Hossain K., Miyata T., Suzuki H., and Nakashima I. Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells. Scandinavian J. Immunol. (the 11th International Congress of Immunology abstract book for 25th July, 2001) Vol. 54 (Suppl. 1), pp. 17 (abstract)
21. Hossain K., Akhand A. A., Kawamoto Y., Takeda K., Yoshihara M., Suzuki H., and Nakashima I. Arsenite triggers membrane rafts-linked apoptotic and anti-apoptotic signals. Scandinavian J. Immunol. (the 11th International Congress of Immunology abstract book for 25th July, 2001) Vol. 54 (Suppl. 1), pp. 17 (abstract)